Dr. Rhonda Patrick, a PhD biomedical scientist who has spent the better part of two decades in molecular aging research, walks through the growing stack of evidence that omega-3 doesn’t just make you feel better, it measurably slows aging inside your cells. She explains epigenetic clocks like DNA GrimAge, developed in Steve Horvath’s lab to predict time to death, and how studies plugging omega-3 intake into these clocks consistently find it slows the rate at which they tick forward. The strongest evidence is the DO-HEALTH trial, a two-year randomized controlled trial in healthy older adults where omega-3 was the lever that slowed biological aging, with added benefit when combined with vitamin D and resistance training, plus fewer infections, fewer falls, less frailty, and lower invasive cancer risk. She covers why the dose matters and differs by sex, why low omega-3 is linked to a 50 percent higher Alzheimer’s risk, how higher levels track with a larger hippocampus, and why the common thread is chronic inflammation, one of the primary engines driving the biological clock. Roughly 90 percent of people are leaving that lever untouched. In this video, she discusses: – How omega-3 slows biological aging measured by epigenetic clocks – The randomized trial where omega-3 was the lever that slowed aging – Why the effective dose differs between men and women – The link between omega-3, Alzheimer’s risk, and hippocampus size – Why chronic inflammation is one of the main engines of aging Sources cited in this video: Bischoff-Ferrari et al. (2025), Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging (DO-HEALTH), Nature Aging https://ift.tt/7pFOezc Lu, Horvath et al. (2019), DNA methylation GrimAge strongly predicts lifespan and healthspan, Aging https://ift.tt/R5ckwQs Wu et al. (2024), Dose-response relationship of dietary omega-3 fatty acids on slowing phenotypic age acceleration, Frontiers in Nutrition https://ift.tt/4FUJriP McBurney, Harris et al. (2021), Using an erythrocyte fatty acid fingerprint to predict risk of all-cause mortality: the Framingham Offspring Cohort, American Journal of Clinical Nutrition https://ift.tt/oQGi6Eu DISCLAIMER: This channel provides health and fitness commentary and analysis for educational and informational purposes only. Views expressed by guests are their own and do not constitute medical advice. Always consult a qualified healthcare professional before starting any new supplement or making changes to your diet. #omega3 #longevity #biologicalaging Scientists Found a Supplement Combo That Actually Slows Aging – Dr Rhonda Patrick
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